Identification

Author

Kilgore PE, Ksiakzek TG, Rollin PE, Mills JN, Villagra MR, et al.

Title

Treatment of Bolivian Hemorrhagic Fever with Intravenous Ribavirin

Year

1997

Publication type

Article

Journal

International Reports

Created

2015-07-29 14:37:27.640957+00:00

Modified

2016-08-10 18:28:09.597122+00:00

Details

Volume

24

Number

4

Pages

718-722

Access

Language

English

URL http://cid.oxfordjournals.org/content/24/4/718.full.pdf
Accessed

2016-06-30

Extended information

Abstract

Bolivian hemorrhagic fever (BHF) is a potentially severe febrile illness caused by Machupo virus (family Arenaviridae). Initial symptoms include headache, fever, arthralgia, and myalgia. In the later stages of this illness, patients may develop hemorrhagic manifestations including subconjunctival hemorrhage, epistaxis, hematemesis, melena, and hematuria, as well as neurological signs including tremor, seizures, and coma. During the BHF epidemics of the 1960s, convalescent-phase immune plasma from survivors of BHF was administered to selected patients infected with Machupo virus. However, there is currently a paucity of survivors of BHF who can donate immune plasma, and there is no active program for collection and storage of BHF immune plasma; therefore, we had the opportunity to offer intravenous ribavirin to two of three patients with this potentially life-threatening infection. One patient with laboratory-confirmed Machupo virus infection who received ribavirin recovered without sequelae, as did a second patient with suspected BHF whose epidemiological and clinical features were similar to those of the first patient. This report describes the first use of intravenous ribavirin therapy for BHF in humans, and the results suggest the need for more extensive clinical studies to assess the usefulness of ribavirin for treating BHF.