Identification

Author

Chesson HW, Kirkcaldy RD, Gift TL, Owusu-Edusei L, Weinstock HS

Title

Ciprofloxacin resistance and Gonorrhea incidence rates in 17 cities, United States, 1991–2006

Year

2014

Publication type

Article

Journal

Emerging Infectious Diseases

Created

2016-03-01 17:31:27.258679+00:00

Modified

2016-08-09 19:15:53.749934+00:00

Details

Institution

CDC

Volume

20

Number

4

Document role

Informational Material

Access

Language

English

URL http://wwwnc.cdc.gov/eid/article/20/4/13-1288_article
DOI

10.3201/eid2004.131288

Accessed

2016-05-24

Extended information

Abstract

Antimicrobial drug resistance can hinder gonorrhea prevention and control efforts. In this study, we analyzed historical ciprofloxacin resistance data and gonorrhea incidence data to examine the possible effect of antimicrobial drug resistance on gonorrhea incidence at the population level. We analyzed data from the Gonococcal Isolate Surveillance Project and city-level gonorrhea incidence rates from surveillance data for 17 cities during 1991–2006. We found a strong positive association between ciprofloxacin resistance and gonorrhea incidence rates at the city level during this period. Their association was consistent with predictions of mathematical models in which resistance to treatment can increase gonorrhea incidence rates through factors such as increased duration of infection. These findings highlight the possibility of future increases in gonorrhea incidence caused by emerging cephalosporin resistance.